Out of nowhere, suburban housewife Mary Alice Young takes her own life. The focus remains on her four friends and from her heavenly perch, Mary Alice sees all and offers her own twisted take on the weekly goings-on.
The mystery continues around Bree's new husband as he is suspected of cheating on his wife and killing a woman named Monique. The housewives get together to complete the mystery while trying to keep their already crazy individual lives sustained.